A new drug bear hugs an undruggable cancer protein
For decades, the protein driving most pancreatic cancers was considered impossible to target because its surface was too smooth for medicine to grip.
Pancreatic cancer is notoriously lethal because it is often invisible until it has already spread. For patients diagnosed with metastatic stages of the disease between 2015 and 2021, the five year survival rate was a staggering three percent. The primary driver of this growth is a mutated gene called KRAS, which acts like a broken light switch stuck in the on position, commanding cells to multiply without end.
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